Safety Exercise extreme caution when switching hydromorphone concentrations or interchanging to other injectable opioid products (eg, morphine). Equianalgesic dosing conversions are based on limited data and do not account for patient specific factors (eg, end organ function, pharmacogenomics) or incomplete cross-tolerance between opioids. No equianalgesic dosing conversion factors are universally accepted.[7-8] https://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=329&loginreturnUrl=SSOCheckOnly
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